“Chest pain” is a symptom with many possible sources - from harmless muscle strain to life-threatening conditions of the heart, lungs, and great vessels. Dangerous causes can masquerade as “ordinary” pain, so significant symptoms require prompt evaluation.
Likely sources: heart, lungs/pleura, chest wall/nerves, esophagus & stomach.
Pain character can suggest a cause, but self-diagnosis is not recommended.
Basic screening: exam + ECG + chest X-ray (with extended tests as indicated).
If red flags are present, seek urgent medical care.
Acute coronary syndrome (ischemia/myocardial infarction)
Pericarditis, myocarditis
Pulmonary embolism (PE)
Pneumonia, pleurisy
Pneumothorax (air in the pleural space)
Costochondritis/Tietze syndrome
Intercostal neuralgia, muscle strain
Rib contusion/fracture
GERD/reflux, esophageal spasm
Peptic ulcer disease (referred pain)
Shingles (herpes zoster)
Anxiety/panic attacks
Myocardial ischemia: pressure/tightness behind the sternum; may radiate to left arm/neck/jaw; shortness of breath, cold sweat, nausea.
Pleurisy/pneumonia: sharp, stabbing pain worse with deep breath or cough; possible fever and weakness.
Pneumothorax: sudden “knife-like” pain with dyspnea, often after exertion/trauma; more common in tall, slim smokers.
Musculoskeletal pain: localized; reproduced by palpation or movement.
Reflux (GERD): burning behind the sternum after meals/at night; relief with antacids.
PE: sudden pleuritic pain, shortness of breath, tachycardia; sometimes hemoptysis.
Sudden severe chest pain with shortness of breath, fainting, or marked weakness.
Crushing/burning pain radiating to the left arm or jaw plus cold sweat or nausea.
Coughing up blood, blue lips/fingers, very fast or irregular pulse.
Chest trauma with deformity or sharp worsening on breathing.
High fever (≥38.5 °C) with significant breathlessness/toxicity.
Cardiac: age, hypertension, diabetes, dyslipidemia, smoking, family history of early CVD.
PE: recent surgery/immobilization/long flight, pregnancy, OCP/HRT, active cancer, thrombophilia.
Pneumothorax: tall/slim habitus, smoking, chronic lung disease, recent procedure/trauma.
GERD: obesity, late meals, alcohol, hiatal hernia, certain medications.
Clinical exam: vital signs, oxygen saturation, inspection and palpation of the chest wall.
Rapid tests: ECG, pulse oximetry; troponin if ischemia is suspected.
Imaging:
Chest X-ray as the first-line test in many scenarios.
CT pulmonary angiography for suspected PE (guided by risk scores/D-dimer).
Point-of-care ultrasound (where available) to look for pleural/pericardial effusion.
Laboratory: CBC, CRP; D-dimer by pretest probability; basic metabolic panel as indicated.
Additional: GI evaluation (reflux/spasm), dermatology (rash), spirometry (asthma/COPD) as needed.
Rest; avoid exertion; keep a brief symptom log (onset, duration, triggers, associated signs).
A short course of over-the-counter analgesics only if safe for you (e.g., no ulcer/bleeding risks). Do not self-start antibiotics.
Avoid smoking and alcohol; ventilate and humidify the room.
If symptoms worsen or red flags appear, switch to emergency care immediately.
Start with a general practitioner/family doctor.
Based on findings, you may be referred to a cardiologist, pulmonologist, gastroenterologist, trauma/orthopedics, neurologist, or dermatologist (if rash is present).